Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

Redshaw, Carl, Watkins, Scott, Humphrey, Simon M., Bulman Page, Philip C., Ashby, Shane, Chao, Yimin, Herbert, Christopher J. and Mueller, Anja (2013) Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation. RSC Advances, 3 (46). pp. 23963-23966. ISSN 2046-2069

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Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024) Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis (former - to 2025) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology (former - to 2025) Faculty of Science > Research Groups > Energy Materials Laboratory (former - to 2025) Faculty of Science > Research Groups > Pharmacology and Biological Chemistry
Depositing User:	Pure Connector
Date Deposited:	06 Nov 2013 12:22
Last Modified:	28 Jan 2026 00:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/44275
DOI:	10.1039/c3ra43207f

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