Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

Redshaw, Carl, Watkins, Scott, Humphrey, Simon M., Bulman Page, Philip C., Ashby, Shane, Chao, Yimin ORCID: https://orcid.org/0000-0002-8488-2690, Herbert, Christopher J. and Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 (2013) Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation. RSC Advances, 3 (46). pp. 23963-23966. ISSN 2046-2069

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Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024) Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Molecular and Tissue Pharmacology Faculty of Science > Research Groups > Energy Materials Laboratory
Depositing User:	Pure Connector
Date Deposited:	06 Nov 2013 12:22
Last Modified:	24 Sep 2024 10:44
URI:	https://ueaeprints.uea.ac.uk/id/eprint/44275
DOI:	10.1039/c3ra43207f

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