Ion-sensitive “isothermal” responsive polymers prepared in water

Magnusson, Johannes Pall, Khan, Adnan, Pasparakis, George, Saeed, Aram Omer ORCID:, Wang, Wenxin and Alexander, Cameron (2008) Ion-sensitive “isothermal” responsive polymers prepared in water. Journal of the American Chemical Society, 130 (33). pp. 10852-10853. ISSN 0002-7863

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Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by ±40 °C following addition of Hofmeister series salts. A “hybrid” block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017)
Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User: Pure Connector
Date Deposited: 23 Oct 2013 10:34
Last Modified: 04 Jul 2023 16:30
DOI: 10.1021/ja802609r

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