Chemistry of polymer and ceramic-based injectable scaffolds and their applications in regenerative medicine

Rahman, C. V., Saeed, Aram ORCID: https://orcid.org/0000-0003-2903-5875, White, L. J., Gould, T. W. A., Kirby, G. T. S., Sawkins, M. J., Alexander, C., Rose, F. R. A. J. and Shakesheff, K. M. (2012) Chemistry of polymer and ceramic-based injectable scaffolds and their applications in regenerative medicine. Chemistry of Materials, 24 (5). pp. 781-795. ISSN 0897-4756

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Abstract

Injectable scaffolds are a class of materials that stimulate the regeneration of functional tissue within the body. These materials are attracting interest in regenerative medicine because they allow tissue repair to occur after minimally invasive administration. From a chemistry perspective these materials present new challenges because they must convert from an injectable material to a solid or gel with appropriate kinetics and without damaging surrounding tissues. Furthermore, the material may have to carry living cells or sensitive drug molecules into the body. The demands placed on these materials have stimulated research into novel chemical and physical mechanisms of forming porous structures within aqueous conditions. This review examines the underlying chemistry of a number of classes of injectable scaffolds and sets out challenges for these materials in the future.

Item Type:	Article
Uncontrolled Keywords:	injectable scaffolds,polymers,hydrogels,regenerative medicine,bone cement
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	23 Oct 2013 11:44
Last Modified:	24 Sep 2024 10:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43812
DOI:	10.1021/cm202708n

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