Synthesis and structural study of two new heparin-like hexasaccharides

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Lucas, Ricardo, Angulo, Jesús ORCID: https://orcid.org/0000-0001-7250-5639, Nieto, Pedro M. and Martín-Lomas, Manuel (2003) Synthesis and structural study of two new heparin-like hexasaccharides. Organic & Biomolecular Chemistry, 1 (13). pp. 2253-2266. ISSN 1477-0520

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Abstract

Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.

Item Type:	Article
Uncontrolled Keywords:	molecular structure,protein structure, secondary,sequence alignment,models, molecular,oligosaccharides,molecular sequence data,carbohydrate sequence,protein structure, tertiary,heparin,protein conformation,magnetic resonance spectroscopy
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Related URLs:	https://pubs.rsc.org/en/content/articlel...
Depositing User:	Pure Connector
Date Deposited:	21 Oct 2013 19:20
Last Modified:	24 Sep 2024 10:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43767
DOI:

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