Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the C and S conformations of a bioactive heparin-like hexasaccharide

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Canales, Angeles, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Ojeda, Rafael, Bruix, Marta, Fayos, Rosa, Lozano, Rosa, Giménez-Gallego, Guillermo, Martín-Lomas, Manuel, Nieto, Pedro M. and Jiménez-Barbero, Jesús (2005) Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the C and S conformations of a bioactive heparin-like hexasaccharide. Journal of the American Chemical Society, 127 (16). pp. 5778-5779. ISSN 0002-7863

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Abstract

The first direct NMR determination of the conformation of a conformationally flexible heparin-like hexasaccharide bound to a key receptor, FGF-1, is described. The determination has been based on the use of a C-labeled protein and a regular C sugar. FGF-1 recognizes several conformations of the iduronic moieties of the hexasaccharide. Therefore, this case is different than that described for the controversial recognition of heparin-like saccharides by AT-III, which seems to recognize just one conformation of the iduronic acid residues.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Pure Connector
Date Deposited:	21 Oct 2013 20:08
Last Modified:	24 Oct 2022 04:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43756
DOI:	10.1021/ja043363y

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