Canales, Angeles, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Ojeda, Rafael, Bruix, Marta, Fayos, Rosa, Lozano, Rosa, Giménez-Gallego, Guillermo, Martín-Lomas, Manuel, Nieto, Pedro M. and Jiménez-Barbero, Jesús
(2005)
Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the C and S conformations of a bioactive heparin-like hexasaccharide.
Journal of the American Chemical Society, 127 (16).
pp. 5778-5779.
ISSN 0002-7863
Abstract
The first direct NMR determination of the conformation of a conformationally flexible heparin-like hexasaccharide bound to a key receptor, FGF-1, is described. The determination has been based on the use of a C-labeled protein and a regular C sugar. FGF-1 recognizes several conformations of the iduronic moieties of the hexasaccharide. Therefore, this case is different than that described for the controversial recognition of heparin-like saccharides by AT-III, which seems to recognize just one conformation of the iduronic acid residues.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy |
UEA Research Groups: | Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter |
Related URLs: | |
Depositing User: | Pure Connector |
Date Deposited: | 21 Oct 2013 20:08 |
Last Modified: | 24 Oct 2022 04:49 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/43756 |
DOI: | 10.1021/ja043363y |
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