Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Van den Bossche, Jeroen, Al-Jamal, Wafa' T, Tian, Bowen, Nunes, Antonio, Fabbro, Chiara, Bianco, Alberto, Prato, Maurizio and Kostarelos, Kostas (2010) Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. Chemical communications (Cambridge, England), 46 (39). pp. 7379-7381. ISSN 1364-548X

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Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Item Type: Article
Uncontrolled Keywords: microscopy, electron, transmission,base sequence,electrophoresis, polyacrylamide gel,humans,dna primers,aptamers, nucleotide,biological transport,cell line, tumor,receptors, cell surface,nanotubes, carbon
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 05 Oct 2013 00:55
Last Modified: 21 Apr 2020 21:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/43578
DOI: 10.1039/c0cc02092c

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