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MacEwan, David, Bowles, Kristian 
ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart
(2013)
Emerging therapy targeting tyrosine-protein kinase BTK: potential for ibrutinib and other BTK inhibitors.
Drugs of the Future, 38 (8).
pp. 569-573.
ISSN 2013-0368
Abstract
Tyrosine-protein kinase BTK (Bruton tyrosine kinase) plays a critical role in the B cell receptor signaling pathway, and as such, mediates many immune responses. Recent studies targeting BTK with small-molecule inhibitors have shown these agents to be effective with relatively low systemic toxicity. BTK inhibitors, such as ibrutinib, CC-292 (AVL-292), ONO-4059 and HM-71224,, are proving to be impressively effective for treating B cell malignancies such as chronic myeloid leukemia and lymphomas. Other diseases that may be treatable with BTK inhibitors include multiple myeloma, as well as autoimmune conditions such as rheumatoid arthritis and lupus. Here, we describe the function of BTK and the potential of the new breed of BTK inhibitors for the clinical treatment of BTK-dependent conditions.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 05 Oct 2013 00:54 |
| Last Modified: | 20 Jun 2024 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/43566 |
| DOI: | 10.1358/dof.2013.38.8.1998163 |
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