Interferon treatment suppresses enteric adenovirus infection in a model gastrointestinal cell-culture system

Sherwood, Victoria, King, Elizabeth, Tötemeyer, Sabine, Connerton, Ian and Mellits, Kenneth H (2012) Interferon treatment suppresses enteric adenovirus infection in a model gastrointestinal cell-culture system. Journal of General Virology, 93 (3). pp. 618-623. ISSN 0022-1317

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Abstract

Exposure to interferon results in the rapid transcriptional induction of genes, many of which function to create an antiviral environment in potential host cells. For the majority of adenoviruses, replication is unaffected by the actions of interferon. It has previously been shown, using non-gastrointestinal cells, that the species F human adenoviruses are sensitive to the action of interferon. Here, we have developed an enterocyte-like cell-culture model to re-evaluate this question, and determined the effects of interferon on species F adenovirus during infection of gastrointestinal cells. We show that species F adenovirus type 40 is sensitive to the effects of interferon in gastrointestinal-like cells, which may help to explain its fastidious growth in culture.

Item Type: Article
Uncontrolled Keywords: adenoviridae,adenovirus infections, human,humans,interferons,cell culture techniques,chemoprevention,antiviral agents,models, theoretical,gastrointestinal tract
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 01 Oct 2013 00:58
Last Modified: 24 Jul 2019 18:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/43503
DOI: 10.1099/vir.0.037556-0

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