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ToolsSherwood, Victoria, King, Elizabeth, Tötemeyer, Sabine, Connerton, Ian and Mellits, Kenneth H (2012) Interferon treatment suppresses enteric adenovirus infection in a model gastrointestinal cell-culture system. Journal of General Virology, 93 (3). pp. 618-623. ISSN 0022-1317
Full text not available from this repository.Abstract
Exposure to interferon results in the rapid transcriptional induction of genes, many of which function to create an antiviral environment in potential host cells. For the majority of adenoviruses, replication is unaffected by the actions of interferon. It has previously been shown, using non-gastrointestinal cells, that the species F human adenoviruses are sensitive to the action of interferon. Here, we have developed an enterocyte-like cell-culture model to re-evaluate this question, and determined the effects of interferon on species F adenovirus during infection of gastrointestinal cells. We show that species F adenovirus type 40 is sensitive to the effects of interferon in gastrointestinal-like cells, which may help to explain its fastidious growth in culture.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adenoviridae,adenovirus infections, human,humans,interferons,cell culture techniques,chemoprevention,antiviral agents,models, theoretical,gastrointestinal tract |
| Faculty \ School: | Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) |
| Depositing User: | Pure Connector |
| Date Deposited: | 01 Oct 2013 00:58 |
| Last Modified: | 24 Oct 2022 04:41 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/43503 |
| DOI: | 10.1099/vir.0.037556-0 |
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