Cytokine response to acute running in recreationally-active and endurance-trained men

Scott, Jonathan P R, Sale, Craig, Greeves, Julie P, Casey, Anna, Dutton, John and Fraser, William D (2013) Cytokine response to acute running in recreationally-active and endurance-trained men. European Journal of Applied Physiology, 113 (7). pp. 1871-1882. ISSN 1439-6319

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Abstract

To compare the cytokine response to exhaustive running in recreationally-active (RA) and endurance-trained (ET) men. Eleven RA men (VO 55 ± 7 mL·min·kg ) and 10 ET men (VO 68 ± 7 mL·min ·kg) followed a controlled diet and refrained from volitional exercise for 8 days. On the fourth day, participants completed 60 min of treadmill running (65 % VO), followed by intermittent running to exhaustion (70 % VO). Fasting blood was obtained at baseline, after 20, 40 and 60 min of exercise, at the end of intermittent exercise, during 2 h of recovery and on four follow-up days (FU1-FU4). Tumour necrosis factor-alpha (TNF-a), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and creatine kinase (CK) were measured. Exercise increased the concentrations of all cytokines and CK, but there were no significant differences between groups. IL-1ß increased (2.2-2.5-fold, P <0.001) during exercise, while TNF-a was increased (1.6-2.0-fold, P <0.001) during exercise and for 2 h post-exercise. IL-6 (71-84-fold, P <0.001) and IL-1ra (52-64-fold, P <0.001) were increased throughout exercise and up to FU1, peaking immediately after exercise and at 1.5-2 h post-exercise, respectively. CK concentrations were increased (P <0.001) throughout exercise and up to FU4, peaking at FU1, but were not associated with changes in any cytokines. Exhaustive running resulted in modest and transient increases in TNF-a and IL-1ß, and more marked and prolonged increases in IL-6 and IL-1ra, but improved training status did not affect this response. Increased CK might indicate either exercise-induced muscle cell disruption or increased cell permeability, although neither appears to have contributed to the increased cytokine concentrations.

Item Type:	Article
Uncontrolled Keywords:	adult,anaerobic threshold,creatine kinase,cytokines,humans,male,running
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Pure Connector
Date Deposited:	25 Sep 2013 01:00
Last Modified:	12 Mar 2024 09:11
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43440
DOI:	10.1007/s00421-013-2615-x

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