Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

Turner, C, Dalton, N, Inaoui, R, Fogelman, I, Fraser, W D and Hampson, G (2013) Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency. The Journal of Clinical Endocrinology and Metabolism, 98 (2). pp. 550-556. ISSN 0021-972X

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Abstract

Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

Item Type: Article
Uncontrolled Keywords: aged,alendronate,bone density,bone density conservation agents,ergocalciferols,female,fibroblast growth factors,humans,male,middle aged,osteoporosis,postmenopause,vitamin d,vitamin d deficiency
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 25 Sep 2013 00:59
Last Modified: 21 Apr 2020 21:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/43437
DOI: 10.1210/jc.2012-2790

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