Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

Turner, C, Dalton, N, Inaoui, R, Fogelman, I, Fraser, W D and Hampson, G (2013) Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency. The Journal of Clinical Endocrinology and Metabolism, 98 (2). pp. 550-556. ISSN 0021-972X

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Abstract

Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

Item Type:	Article
Uncontrolled Keywords:	aged,alendronate,bone density,bone density conservation agents,ergocalciferols,female,fibroblast growth factors,humans,male,middle aged,osteoporosis,postmenopause,vitamin d,vitamin d deficiency
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Pure Connector
Date Deposited:	25 Sep 2013 00:59
Last Modified:	12 Mar 2024 09:11
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43437
DOI:	10.1210/jc.2012-2790

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