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ToolsTolppanen, Anna-Maija, Sayers, Adrian, Fraser, William D., Lewis, Glyn, Zammit, Stanley, McGrath, John and Lawlor, Debbie A. (2012) Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. PLoS One, 7 (7). ISSN 1932-6203
Full text not available from this repository. (Request a copy)Abstract
Objective: Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D and 25(OH)D, have similar associations with psychosis-related outcomes. Methods: We investigated the association between serum 25(OH)D and 25(OH)D concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D and 25(OH)D concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182). Results: Higher 25(OH)D concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value. Conclusions: Our findings of an inverse association of 25(OH)D with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes.
| Item Type: | Article |
|---|---|
| Additional Information: | © 2012 Tolppanen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Sep 2013 01:00 |
| Last Modified: | 19 Oct 2023 01:10 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/43417 |
| DOI: | 10.1371/journal.pone.0041575 |
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