Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

Barrera, Lawrence N., Johnson, Ian T., Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370, Cassidy, Aedin and Belshaw, Nigel J. (2013) Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro. European Journal of Nutrition, 52 (4). pp. 1327-1341.

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Abstract

It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities. This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines.

Item Type:	Article
Additional Information:	Funding information: This work was supported by a joint PhD Studentship by the Norwich Medical School, University of East Anglia and by the BBSRC Institute of Food Research, Norwich, UK, and in part by the Overseas Research Students Awards Scheme (ORSAS), United Kingdom
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences Faculty of Science > School of Environmental Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	20 Aug 2013 05:28
Last Modified:	24 Sep 2024 10:39
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43132
DOI:	10.1007/s00394-012-0442-1

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