Membrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruzi

Butler, Claire and Tyler, Kevin ORCID: https://orcid.org/0000-0002-0647-8158 (2012) Membrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruzi. Cellular Microbiology, 14 (9). pp. 1345-1353. ISSN 1462-5822

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Abstract

It is widely accepted that Trypanosoma cruzi can exploit the natural exocytic response of the host to cell damage, utilizing host cell lysosomes as important effectors. It is, though, increasingly clear that the parasite also exploits endocytic mechanisms which allow for incorporation of plasma membrane into the parasitophorous vacuole. Further, that these endocytic mechanisms are involved in cross-talk with the exocytic machinery, in the recycling of vesicles and in the manipulation of the cytoskeleton. Here we review the mechanisms by which T.?cruzi exploits features of the exocytic and endocytic pathways in epithelial and endothelial cells and the evidence for cross-talk between these pathways.

Item Type:	Article
Additional Information:	© 2012 Blackwell Publishing Ltd.
Uncontrolled Keywords:	trypanosoma cruzi,endocytosis,animals,humans,vacuoles,exocytosis,models, biological,host-pathogen interactions
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	Pure Connector
Date Deposited:	26 Jun 2013 09:35
Last Modified:	24 Sep 2024 10:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/42528
DOI:	10.1111/j.1462-5822.2012.01818.x

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