Studies Towards a Total a Synthesis of Tagetitoxin

Pearce, Christopher (2013) Studies Towards a Total a Synthesis of Tagetitoxin. Doctoral thesis, University of East Anglia.

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Tagetitoxin is a phytotoxin produced by the bacterium Pseudomonas syringae pv. tagetis. It
is a selective inhibitor of RNA polymerase III in eukaryotic cells and RNA polymerase in
bacteria. Since its initial isolation and partial characterization, more than thirty years have
passed without a fully characterized structure for tagetitoxin. While much research has been
carried out on the biological aspects of tagetitoxin, particularly with interests towards its
activity as an inhibitor of RNA polymerase, very few published works are available from a
synthetic perspective.
Figure 1: Synthetic intermediates towards tagetitoxin
In this thesis several promising synthetic intermediates towards the goal of tagetitoxin were
synthesized (Figure 1). Herein the previous work related to the biology and synthetic studies
of tagetitoxin and the recent studies conducted in the group towards a total synthesis of the
molecule is described.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Users 2259 not found.
Date Deposited: 02 May 2013 12:16
Last Modified: 02 May 2013 12:16


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