Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes

Livermore, David M. ORCID: https://orcid.org/0000-0002-9856-3703, Mushtaq, Shazad, Morinaka, Akihiro, Ida, Takashi, Maebashi, Kazunori and Hope, Russell (2013) Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes. Journal of Antimicrobial Chemotherapy, 68 (1). pp. 153-158. ISSN 0305-7453

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Abstract

ME1071 is a maleic acid that inhibits metallo-β-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.

Item Type:	Article
Uncontrolled Keywords:	acinetobacter,bacterial proteins,carbapenems,drug synergism,enterobacteriaceae,enzyme inhibitors,humans,maleates,microbial sensitivity tests,beta-lactamases
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Sophie Buckingham
Date Deposited:	05 Mar 2013 10:49
Last Modified:	18 Jun 2026 14:40
URI:	https://ueaeprints.uea.ac.uk/id/eprint/41719
DOI:	10.1093/jac/dks350

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