Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes

Livermore, David M, Mushtaq, Shazad, Morinaka, Akihiro, Ida, Takashi, Maebashi, Kazunori and Hope, Russell (2013) Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes. Journal of Antimicrobial Chemotherapy, 68 (1). pp. 153-158. ISSN 0305-7453

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Abstract

ME1071 is a maleic acid that inhibits metallo-β-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.

Item Type: Article
Uncontrolled Keywords: acinetobacter,bacterial proteins,carbapenems,drug synergism,enterobacteriaceae,enzyme inhibitors,humans,maleates,microbial sensitivity tests,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Sophie Buckingham
Date Deposited: 05 Mar 2013 10:49
Last Modified: 21 Apr 2020 16:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/41719
DOI: 10.1093/jac/dks350

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