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Al-Agamy, Mohamed H., Shibl, Atef M., Tawfik, Abdulkader F., Elkhizzi, Noura A. and Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703
(2012)
Extended-spectrum and metallo-beta-lactamases among ceftazidime-resistant Pseudomonas aeruginosa in Riyadh, Saudi Arabia.
Journal of Chemotherapy, 24 (2).
pp. 97-100.
ISSN 1973-9478
Abstract
We investigated the extended-spectrum (ESBLs) and metallo-beta-lactamases (MBLs) among Pseudomonas aeruginosa isolates in Saudi Arabia. Disc susceptibility testing was performed on 200 P. aeruginosa isolates collected during 2010 at the Armed Forces Hospital in Riyadh, with MIC testing and phenotypic screening for ESBLs and MBLs carried out on those found to be ceftazidime resistant. Genes for ESBLs and MBLs were sought by PCR. Thirty-nine (19·5%) P. aeruginosa isolates were ceftazidime resistant, mostly with considerable resistance to other antibiotics except colistin. Twenty-three of these 39 (59%) appeared ESBL positive and 16 (41%) had MBLs. blaVEB, and blaGES genes were found in 20 (86·95%), and 5 (21·74%) of 23 ESBL-positive isolates, respectively whilst blaVIM was detected in all 16 MBL-producers. blaOXA-10-like often accompanied blaVEB, blaVIM or blaGES. Several isolates had similar antibiogram and β-lactamase profiles, and may represent outbreaks; nevertheless, the collection was not dominated by any single clone. This dominance of acquired ceftazidime-inactivating beta-lactamases, often in combination is in contrast to the situation in Europe and the USA, where most ceftazidime resistance in P. aeruginosa is attributable to AmpC and efflux.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Depositing User: | Sophie Buckingham |
| Date Deposited: | 05 Mar 2013 10:50 |
| Last Modified: | 11 Jan 2024 01:20 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/41718 |
| DOI: | 10.1179/1120009X12Z.00000000015 |
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