Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early stage breast cancer: a randomized controlled trial

Scott, E, Daley, A.J, Doll, H, Woodroofe, N, Coleman, R.E, Mutrie, N, Crank, H, Powers, H.J and Saxton, John (2013) Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early stage breast cancer: a randomized controlled trial. Cancer Causes & Control, 24 (1). pp. 181-191. ISSN 0957-5243

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Abstract

Excess body weight at diagnosis and weight gain after breast cancer are associated with poorer long-term prognosis. This study investigated the effects of a lifestyle intervention on body weight and other health outcomes influencing long-term prognosis in overweight women (BMI > 25.0 kg/m2) recovering from early-stage (stage I–III) breast cancer. A total of 90 women treated 3–18 months previously were randomly allocated to a 6-month exercise and hypocaloric healthy eating program (n = 47, aged 55.6 ± 10.2 year) or control group (n = 43, aged 55.9 ± 8.9 year). Women in the intervention group received three supervised exercise sessions per week and individualized dietary advice, supplemented by weekly nutrition seminars. Body weight, waist circumference, waist/hip ratio [WHR], cardiorespiratory fitness, blood biomarkers associated with breast cancer recurrence and cardiovascular disease risk, and quality of life (FACT-B) were assessed at baseline and 6 months. Three-day diet diaries were used to assess macronutrient and energy intakes. A moderate reduction in body weight in the intervention group (median difference from baseline of -1.09 kg; IQR -0.15 to -2.90 kg; p = 0.07) was accompanied by significant reductions in waist circumference (p < 0.001), WHR (p = 0.005), total (p = 0.021) and saturated fat (p = 0.006) intakes, leptin (p = 0.005), total cholesterol (p = 0.046), and resting diastolic blood pressure (p = 0.03). Cardiopulmonary fitness (p < 0.001) and FACT-B quality of life (p = 0.004) also showed significant improvements in the intervention group. These findings suggest that an individualized exercise and a hypocaloric healthy eating program can positively impact upon health outcomes influencing long-term prognosis in overweight women recovering from early-stage breast cancer.

Item Type:	Article
Additional Information:	PubMed PMCID: 23184120
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Allied Health Professions (former - to 2013)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation
Depositing User:	Katherine Humphries
Date Deposited:	05 Feb 2013 11:36
Last Modified:	14 May 2023 23:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/41102
DOI:	10.1007/s10552-012-0104-x

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