Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial

Little, P., Moore, M. V., Turner, S., Rumsby, K., Warner, G., Lowes, J. A., Smith, H., Hawke, C., Leydon, G., Arscott, A., Turner, D. and Mullee, M. (2010) Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. British Medical Journal (BMJ), 340 (feb05 1). c199. ISSN 0959-8138

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Abstract

Objective: To assess the impact of different management strategies in urinary tract infections. Design: Randomised controlled trial. Setting: Primary care. Participants: 309 non-pregnant women aged 18-70 presenting with suspected urinary tract infection. Intervention: Patients were randomised to five management approaches: empirical antibiotics; empirical delayed (by 48 hours) antibiotics; or targeted antibiotics based on a symptom score (two or more of urine cloudiness, urine smell, nocturia, or dysuria), a dipstick result (nitrite or both leucocytes and blood), or a positive result on midstream urine analysis. Self help advice was controlled in each group. Main outcome measures: Symptom severity (days 2 to 4) and duration, and use of antibiotics. Results: Patients had 3.5 days of moderately bad symptoms if they took antibiotics immediately. There were no significant differences in duration or severity of symptoms (mean frequency of symptoms on a 0 to 6 scale: immediate antibiotics 2.15, midstream urine 2.08, dipstick 1.74, symptom score 1.77, delayed antibiotics 2.11; likelihood ratio test for the five groups P=0.177). There were differences in antibiotic use (immediate antibiotics 97%, midstream urine 81%, dipstick 80%, symptom score 90%, delayed antibiotics 77%; P=0.011) and in sending midstream urine samples (immediate antibiotics 23%, midstream urine 89%, dipstick 36%, symptom score 33%, delayed antibiotics 15%; P<0.001). Patients who waited at least 48 hours to start taking antibiotics reconsulted less (hazard ratio 0.57 (95% confidence interval 0.36 to 0.89), P=0.014) but on average had symptoms for 37% longer than those taking immediate antibiotics (incident rate ratio 1.37 (1.11 to 1.68), P=0.003), particularly the midstream urine group (73% longer, 22% to 140%; none of the other groups had more than 22% longer duration). Conclusion: All management strategies achieve similar symptom control. There is no advantage in routinely sending midstream urine samples for testing, and antibiotics targeted with dipstick tests with a delayed prescription as backup, or empirical delayed prescription, can help to reduce antibiotic use. Study registration: National Research Register N0484094184 ISRCTN: 03525333.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Health Economics Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Users 2731 not found.
Date Deposited:	05 Dec 2012 11:13
Last Modified:	06 Feb 2025 02:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/40385
DOI:	10.1136/bmj.c199

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