A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia

Maidment, ID, Fox, C ORCID: https://orcid.org/0000-0001-9480-5704 and Boustani, M (2005) A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia. Acta Psychiatrica Scandinavica, 111 (6). pp. 403-409. ISSN 0001-690X

Full text not available from this repository. (Request a copy)

Abstract

Objective: To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD). Method: MEDLINE (1966 – December 2004), PsychINFO (1972 – December 2004), EMBASE (1980 – December 2004), CINHAL (1982 – December 2004), and the Cochrane Collaboration were searched in December 2004. Results: Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms. Conclusion: Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms – in particular tremor – may limit the utility of cholinesterase inhibitors.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Psychological Sciences (former - to 2018)
Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research
Depositing User: Users 2731 not found.
Date Deposited: 17 Sep 2012 13:55
Last Modified: 17 Apr 2023 23:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/39565
DOI: 10.1111/j.1600-0447.2005.00516.x

Actions (login required)

View Item View Item