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Maidment, I. D., Fox, C. 
ORCID: https://orcid.org/0000-0001-9480-5704 and Boustani, M.
(2005)
A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia.
Acta Psychiatrica Scandinavica, 111 (6).
pp. 403-409.
ISSN 0001-690X
Abstract
Objective: To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD). Method: MEDLINE (1966 – December 2004), PsychINFO (1972 – December 2004), EMBASE (1980 – December 2004), CINHAL (1982 – December 2004), and the Cochrane Collaboration were searched in December 2004. Results: Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms. Conclusion: Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms – in particular tremor – may limit the utility of cholinesterase inhibitors.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research Faculty of Medicine and Health Sciences > Research Groups > Psychological Sciences (former - to 2018) |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 17 Sep 2012 13:55 |
| Last Modified: | 24 Sep 2024 09:58 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/39565 |
| DOI: | 10.1111/j.1600-0447.2005.00516.x |
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