Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial

Fox, Chris ORCID: https://orcid.org/0000-0001-9480-5704, Crugel, Monica, Maidment, Ian, Auestad, Bjorn Henrik, Coulton, Simon, Treloar, Adrian, Ballard, Clive, Boustani, Malaz, Katona, Cornelius and Livingston, Gill (2012) Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial. PLoS One, 7 (5). ISSN 1932-6203

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Abstract

Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary hypothesis, memantine is superior to placebo for clinically significant agitation, in patients with moderate-to-severe AD.

Item Type: Article
Uncontrolled Keywords: aged,aged, 80 and over,alzheimer disease,dementia,female,humans,male,memantine,psychomotor agitation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Users 2731 not found.
Date Deposited: 11 Sep 2012 12:17
Last Modified: 22 Oct 2022 20:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/39514
DOI: 10.1371/journal.pone.0035185

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