Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial

Fox, Chris, Crugel, Monica, Maidment, Ian, Auestad, Bjorn Henrik, Coulton, Simon, Treloar, Adrian, Ballard, Clive, Boustani, Malaz, Katona, Cornelius and Livingston, Gill (2012) Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial. PLoS One, 7 (5). ISSN 1932-6203

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Abstract

Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary hypothesis, memantine is superior to placebo for clinically significant agitation, in patients with moderate-to-severe AD.

Item Type:	Article
Uncontrolled Keywords:	aged,aged, 80 and over,alzheimer disease,dementia,female,humans,male,memantine,psychomotor agitation
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Psychological Sciences (former - to 2018) Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research
Depositing User:	Users 2731 not found.
Date Deposited:	11 Sep 2012 12:17
Last Modified:	06 Feb 2025 01:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39514
DOI:	10.1371/journal.pone.0035185

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