Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial

Fox, Chris ORCID: https://orcid.org/0000-0001-9480-5704, Crugel, Monica, Maidment, Ian, Auestad, Bjorn Henrik, Coulton, Simon, Treloar, Adrian, Ballard, Clive, Boustani, Malaz, Katona, Cornelius and Livingston, Gill (2012) Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial. PLoS One, 7 (5). ISSN 1932-6203

Full text not available from this repository. (Request a copy)

Abstract

Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary hypothesis, memantine is superior to placebo for clinically significant agitation, in patients with moderate-to-severe AD.

Item Type:	Article
Uncontrolled Keywords:	aged,aged, 80 and over,alzheimer disease,dementia,female,humans,male,memantine,psychomotor agitation
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Psychological Sciences (former - to 2018) Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research
Depositing User:	Users 2731 not found.
Date Deposited:	11 Sep 2012 12:17
Last Modified:	21 Apr 2023 04:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39514
DOI:	10.1371/journal.pone.0035185

Actions (login required)

View Item