Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids

Zhang, Qingzhi, Raheem, K. Saki, Botting, Nigel P., Slawin, Alexandra M.z., Kay, Colin D. and O'Hagan, David (2012) Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids. Tetrahedron, 68 (22). pp. 4194-4201.

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Abstract

Epidemiological studies indicate that favonoid intake is inversely associated with the risk of coronary heart disease, yet the mechanisms responsible for their bioactivity are still a matter of debate. Based on the rapid and extensive metabolism of most favonoids, their health effects most likely result from the biological activity of their metabolites. However, a lack of commercially available compounds/standards has prevented the study of metabolite bioactivity and resulted in a focus on non-physiologically relevant precursor/parent structures. This paper details the synthesis of a series of phenolic glucuronide 1a-e and sulfate 2a-e derivates as candidate metabolites for use as reference compounds in metabolic profling studies and for the exploration of favonoid bioactivity.

Item Type:	Article
Uncontrolled Keywords:	flavanoids,metabolites,phenolic glucuronides,phenolic sulfates,synthesis
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Colin Kay
Date Deposited:	17 Apr 2013 11:24
Last Modified:	21 Apr 2023 23:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39468
DOI:	10.1016/j.tet.2012.03.100

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