CCL3 induced migration occurs independently of intracellular calcium release

Moyano Cardaba, C., Jacques, R. O., Barrett, J. E., Hassell, K. M., Kavanagh, A., Remington, F. C., Tse, T. and Mueller, A. ORCID: https://orcid.org/0000-0003-0774-0434 (2012) CCL3 induced migration occurs independently of intracellular calcium release. Biochemical and Biophysical Research Communications, 418 (1). pp. 17-21. ISSN 1090-2104

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Abstract

The molecular signalling pathway of cell migration and whether it can occur independently of the release of intracellular calcium is still not completely understood. Therefore we investigated here the molecular mechanisms of CCL3 induced cell migration and the importance of intracellular calcium for chemotaxis in more detail. We show that CCL3 induced cell migration is dependent on activation of PLC. Several PKC inhibitors block the release of intracellular calcium independently of CCL3 activation and do not affect cell migration. This confirms that the release of intracellular calcium is not necessary for chemotaxis towards CCL3 and that PKC inhibitors should be used with caution in calcium release assays.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Molecular and Tissue Pharmacology Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017)
Depositing User:	Users 2731 not found.
Date Deposited:	07 Aug 2012 09:44
Last Modified:	12 Jun 2024 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39291
DOI:	10.1016/j.bbrc.2011.12.081

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