Biocatalytic production of tetrahydroisoquinolines

Ruff, BM, Bräse, S and O'Connor, SE (2012) Biocatalytic production of tetrahydroisoquinolines. Tetrahedron Letters, 53 (9). pp. 1071-1074.

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The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: Rhiannon Harvey
Date Deposited: 21 Mar 2012 15:30
Last Modified: 24 Jul 2019 13:16
DOI: 10.1016/j.tetlet.2011.12.089

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