Biocatalytic production of tetrahydroisoquinolines

Ruff, Bettina M., Bräse, S. and O'Connor, Sarah E. (2012) Biocatalytic production of tetrahydroisoquinolines. Tetrahedron Letters, 53 (9). pp. 1071-1074.

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Abstract

The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Rhiannon Harvey
Date Deposited:	21 Mar 2012 15:30
Last Modified:	12 Oct 2025 09:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/38418
DOI:	10.1016/j.tetlet.2011.12.089

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