In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors

Pal, C., Cammidge, A. N. ORCID: https://orcid.org/0000-0001-7912-4310, Cook, M. J., Sosa-Sanchez, J. L., Sharma, A. K. and Ray, A. K. (2012) In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors. Journal of The Royal Society Interface, 9 (66). pp. 183-189. ISSN 1742-5689

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Abstract

Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and l-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Chemistry of Light and Energy Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Users 2731 not found.
Date Deposited:	21 Mar 2012 13:55
Last Modified:	24 Sep 2024 08:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/38401
DOI:	10.1098/rsif.2010.0726

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