Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor

Benelkebir, Hanae, Donlevy, Alison M., Packham, Graham and Ganesan, A. (2011) Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor. Organic Letters, 13 (24). pp. 6334-6337. ISSN 1523-7060

Full text not available from this repository.

Abstract

Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same strain of Burkholderia thailandensis. Burkholdac B is the most potent among depsipeptide histone deacetylase inhibitors in growth inhibition of the MCF7 breast cancer cell line with an IC50 of 60 pM. © 2011 American Chemical Society.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rhiannon Harvey
Date Deposited:	14 Mar 2012 15:16
Last Modified:	28 Mar 2025 02:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/38291
DOI:	10.1021/ol202197q

Actions (login required)

View Item