Benelkebir, Hanae, Donlevy, Alison M., Packham, Graham and Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999
(2011)
Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor.
Organic Letters, 13 (24).
pp. 6334-6337.
ISSN 1523-7060
Abstract
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same strain of Burkholderia thailandensis. Burkholdac B is the most potent among depsipeptide histone deacetylase inhibitors in growth inhibition of the MCF7 breast cancer cell line with an IC50 of 60 pM. © 2011 American Chemical Society.
Item Type: | Article |
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Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Science > School of Pharmacy |
Depositing User: | Rhiannon Harvey |
Date Deposited: | 14 Mar 2012 15:16 |
Last Modified: | 22 Oct 2022 22:32 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/38291 |
DOI: | 10.1021/ol202197q |
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