Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor

Benelkebir, Hanae, Donlevy, Alison M., Packham, Graham and Ganesan, A. (2011) Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor. Organic Letters, 13 (24). pp. 6334-6337. ISSN 1523-7060

Full text not available from this repository. (Request a copy)

Abstract

Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same strain of Burkholderia thailandensis. Burkholdac B is the most potent among depsipeptide histone deacetylase inhibitors in growth inhibition of the MCF7 breast cancer cell line with an IC50 of 60 pM. © 2011 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rhiannon Harvey
Date Deposited: 14 Mar 2012 15:16
Last Modified: 31 Oct 2019 13:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/38291
DOI: 10.1021/ol202197q

Actions (login required)

View Item View Item