Tools
Tools
Benelkebir, Hanae, Donlevy, Alison M., Packham, Graham and Ganesan, A. 
ORCID: https://orcid.org/0000-0003-4862-7999
(2011)
Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor.
Organic Letters, 13 (24).
pp. 6334-6337.
ISSN 1523-7060
Abstract
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same strain of Burkholderia thailandensis. Burkholdac B is the most potent among depsipeptide histone deacetylase inhibitors in growth inhibition of the MCF7 breast cancer cell line with an IC50 of 60 pM. © 2011 American Chemical Society.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 14 Mar 2012 15:16 |
| Last Modified: | 24 Sep 2024 09:02 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/38291 |
| DOI: | 10.1021/ol202197q |
Actions (login required)
 |
View Item |