Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Pors, Klaus, Loadman, Paul M., Shnyder, Steven D., Sutherland, Mark, Sheldrake, Helen M., Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Patterson, Laurence H. (2011) Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chemical Communications, 47 (44). pp. 12062-12064. ISSN 1359-7345

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Abstract

The identification of an agent that is selectively activated by a cytochrome P450 (CYP) has the potential for tissue specific dose intensification as a means of significantly improving its therapeutic value. Towards this goal, we disclose evidence for the pathway of activation of a duocarmycin analogue, ICT2700, which targets CYP1A1 for biological activity.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Users 2731 not found.
Date Deposited:	13 Mar 2012 15:28
Last Modified:	24 Sep 2024 09:05
URI:	https://ueaeprints.uea.ac.uk/id/eprint/38190
DOI:	10.1039/C1CC15638A

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