New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

Flecks, Silvana, Patallo, Eugenio P., Zhu, Xiaofeng, Ernyei, Aliz J., Seifert, Gotthard, Schneider, Alexander, Dong, Changjiang, Naismith, James H. and van Pée, Karl-Heinz (2008) New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan. Angewandte Chemie International Edition, 47 (49). pp. 9533-9536. ISSN 1521-3773

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Abstract

(Chemical Equation Presented) It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 22 Feb 2012 10:09
Last Modified: 21 Apr 2020 17:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/37346
DOI: 10.1002/anie.200802466

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