Multiple newly identified loci associated with prostate cancer susceptibility

Eeles, Rosalind A., Kote-Jarai, Zsofia, Giles, Graham G., Olama, Ali Amin Al, Guy, Michelle, Jugurnauth, Sarah K., Mulholland, Shani, Leongamornlert, Daniel A., Edwards, Stephen M., Morrison, Jonathan, Field, Helen I., Southey, Melissa C., Severi, Gianluca, Donovan, Jenny L., Hamdy, Freddie C., Dearnaley, David P., Muir, Kenneth R., Smith, Charmaine, Bagnato, Melisa, Ardern-Jones, Audrey T., Hall, Amanda L., O'Brien, Lynne T., Gehr-Swain, Beatrice N., Wilkinson, Rosemary A., Cox, Angie, Lewis, Sarah, Brown, Paul M., Jhavar, Sameer G., Tymrakiewicz, Malgorzata, Lophatananon, Artitaya, Bryant, Sarah L., Horwich, Alan, Huddart, Robert A., Khoo, Vincent S., Parker, Christopher C., Woodhouse, Christopher J., Thompson, Alan, Christmas, Tim, Ogden, Chris, Fisher, Cyril, Jamieson, Charles, Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042, English, Dallas R., Hopper, John L., Neal, David E. and Easton, Douglas F. (2008) Multiple newly identified loci associated with prostate cancer susceptibility. Nature Genetics, 40 (3). pp. 316-321. ISSN 1546-1718

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Abstract

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 × 10−8 to P = 8.7 × 10−29). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Users 2731 not found.
Date Deposited:	21 Feb 2012 13:34
Last Modified:	04 Mar 2024 16:41
URI:	https://ueaeprints.uea.ac.uk/id/eprint/37296
DOI:	10.1038/ng.90

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