Adherence therapy for medication non-compliant patients with hypertension: a randomised controlled trial

Alhalaiqa, F., Deane, K. H. O. ORCID: https://orcid.org/0000-0002-0805-2708, Nawafleh, A. H., Clark, A. ORCID: https://orcid.org/0000-0003-2965-8941 and Gray, R. (2012) Adherence therapy for medication non-compliant patients with hypertension: a randomised controlled trial. Journal of Human Hypertension, 26 (2). pp. 117-126. ISSN 0950-9240

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Abstract

The objective of this study is to establish the efficacy of adherence therapy (AT) compared with treatment as usual (TAU) in reducing blood pressure (BP) in non-compliant hypertensive patients. This study was designed as a parallel-group single-blind randomised controlled trial. The study was carried out at three general hospital outpatient clinics in Jordan. A total of 136 non-compliant hypertensive patients with a mean baseline BP of 164.5 mm Hg (s.d. 10.0) over 102.2 mm Hg (s.d. 7.0) participated in the study. 7 weekly 20-min sessions of AT in addition to TAU. The main outcome of this study is systolic blood pressure (SBP) at 11-weeks follow-up. In all, 68 patients received TAU and 68 AT. Intention-to-treat analysis included all participants randomised. AT lowered SBP by -23.11 mm Hg (95% CI: -25.85, -20.36) and diastolic BP (DBP) by -15.18 mm Hg (95% CI: -17.55, -12.80) at 11 weeks compared with TAU. Adherence (measured by pill counting) was also improved in the AT group by 37% at 11 weeks compared with TAU. No significant adverse events were reported. AT increases adherence to medication for hypertension which then leads to a clinically important reduction in BP.Journal of Human Hypertension advance online publication, 17 February 2011; doi:10.1038/jhh.2010.133.

Item Type:	Article
Additional Information:	This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Groups > Community and Family Health (former - to 2017) Faculty of Medicine and Health Sciences > Research Groups > Health in Later Life (former - to 2017) Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Rhiannon Harvey
Date Deposited:	15 Feb 2012 12:10
Last Modified:	19 Oct 2023 00:26
URI:	https://ueaeprints.uea.ac.uk/id/eprint/37129
DOI:	10.1038/jhh.2010.133

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