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Grocott, Timothy 
ORCID: https://orcid.org/0000-0002-6321-401X, Johnson, Samuel, Bailey, Andrew P. and Streit, Andrea
(2011)
Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
Nature Communications, 2.
ISSN 2041-1723
Abstract
In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model system, that neural crest-derived transforming growth factor-ßs activate both Smad3 and canonical Wnt signalling in the adjacent ectoderm to position the lens next to the retina. They do so by controlling Pax6 activity: although Smad3 may inhibit Pax6 protein function, its sustained downregulation requires transcriptional repression by Wnt-initiated ß-catenin. We propose that the same neural crest-dependent signalling mechanism is used repeatedly to integrate different components of the eye and suggest a general role for the neural crest in coordinating central and peripheral parts of the sensory nervous system.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Cells and Tissues |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 24 Jan 2012 15:36 |
| Last Modified: | 21 Apr 2023 23:51 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/36458 |
| DOI: | 10.1038/ncomms1269 |
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