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Stuchinskaya, Tanya, Moreno, Miguel, Cook, Michael J., Edwards, Dylan R. 
ORCID: https://orcid.org/0000-0002-3292-2064 and Russell, David A.
(2011)
Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates.
Photochemical & Photobiological Sciences, 10 (5).
pp. 822-831.
ISSN 1474-905X
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Abstract
A 4-component antibody-phthalocyanine-polyethylene glycol-gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc-phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticles via a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Science > Research Groups > Cells and Tissues Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017) |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 24 Oct 2011 13:09 |
| Last Modified: | 24 Sep 2024 09:06 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/35148 |
| DOI: | 10.1039/c1pp05014a |
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