Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

Lee, Kyungwon, Kim, Mi-Na, Choi, Tae Yeal, Cho, Soung-Eun, Lee, Seungok, Whang, Dong Hee, Yong, Dongeun, Chong, Yunsop, Woodford, Neil and Livermore, David M. (2009) Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea. International Journal of Antimicrobial Agents, 33 (6). pp. 520-524. ISSN 1872-7913

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Abstract

Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-ß-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Users 2731 not found.
Date Deposited: 24 Oct 2011 11:11
Last Modified: 21 Apr 2020 17:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/35144
DOI: 10.1016/j.ijantimicag.2008.10.009

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