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Lee, Kyungwon, Kim, Mi-Na, Choi, Tae Yeal, Cho, Soung-Eun, Lee, Seungok, Whang, Dong Hee, Yong, Dongeun, Chong, Yunsop, Woodford, Neil and Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703
(2009)
Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea.
International Journal of Antimicrobial Agents, 33 (6).
pp. 520-524.
ISSN 1872-7913
Abstract
Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-ß-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 24 Oct 2011 11:11 |
| Last Modified: | 23 Oct 2022 01:50 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/35144 |
| DOI: | 10.1016/j.ijantimicag.2008.10.009 |
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