A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Iijima, Yusuke, Munakata, Asami, Shin-ya, Kazuo, Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999, Doi, Takayuki and Takahashi, Takashi (2009) A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A. Tetrahedron Letters, 50 (24). pp. 2970-2972.

Full text not available from this repository. (Request a copy)

Abstract

Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and solution-phase macrolactonization, followed by intramolecular disulfide formation.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Users 2731 not found.
Date Deposited:	20 Oct 2011 10:49
Last Modified:	23 Oct 2022 01:50
URI:	https://ueaeprints.uea.ac.uk/id/eprint/35108
DOI:	10.1016/j.tetlet.2009.04.005

Actions (login required)

View Item