A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Iijima, Yusuke, Munakata, Asami, Shin-ya, Kazuo, Ganesan, A., Doi, Takayuki and Takahashi, Takashi (2009) A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A. Tetrahedron Letters, 50 (24). pp. 2970-2972.

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Abstract

Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and solution-phase macrolactonization, followed by intramolecular disulfide formation.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Users 2731 not found.
Date Deposited: 20 Oct 2011 10:49
Last Modified: 31 Oct 2019 13:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/35108
DOI: 10.1016/j.tetlet.2009.04.005

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