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Iijima, Yusuke, Munakata, Asami, Shin-ya, Kazuo, Ganesan, A. 
ORCID: https://orcid.org/0000-0003-4862-7999, Doi, Takayuki and Takahashi, Takashi
(2009)
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A.
Tetrahedron Letters, 50 (24).
pp. 2970-2972.
Abstract
Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and solution-phase macrolactonization, followed by intramolecular disulfide formation.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 20 Oct 2011 10:49 |
| Last Modified: | 24 Sep 2024 09:18 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/35108 |
| DOI: | 10.1016/j.tetlet.2009.04.005 |
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