Novel inducers of the envelope stress response BaeSR in Salmonella Typhimurium: BaeR is critically required for tungstate waste disposal

Appia-Ayme, Corinne ORCID: https://orcid.org/0000-0002-8315-0789, Patrick, Elaine, Sullivan, Matthew J. ORCID: https://orcid.org/0000-0003-2276-3132, Alston, Mark J., Field, Sarah J., AbuOun, Manal, Anjum, Muna F. and Rowley, Gary ORCID: https://orcid.org/0000-0002-5421-4333 (2011) Novel inducers of the envelope stress response BaeSR in Salmonella Typhimurium: BaeR is critically required for tungstate waste disposal. PLoS One, 6 (8). ISSN 1932-6203

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Abstract

The RpoE and CpxR regulated envelope stress responses are extremely important for SalmonellaTyphimurium to cause infection in a range of hosts. Until now the role for BaeSR in both the Salmonella Typhimurium response to stress and its contribution to infection have not been fully elucidated. Here we demonstrate stationary phase growth, iron and sodium tungstate as novel inducers of the BaeRregulon, with BaeR critically required for Salmonella resistance to sodium tungstate. We show that functional overlap between the resistance nodulation-cell division (RND) multidrug transporters, MdtA, AcrD and AcrB exists for the waste disposal of tungstate from the cell. We also point to a role for enterobactinsiderophores in the protection of enteric organisms from tungstate, akin to the scenario in nitrogen fixing bacteria. Surprisingly, BaeR is the first envelope stress response pathway investigated in S. Typhimurium that is not required for murine typhoid in either ityS or ityR mouse backgrounds. BaeR is therefore either required for survival in larger mammals such as pigs or calves, an avian host such as chickens, or survival out with the host altogether where Salmonella and related enterics must survive in soil and water.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	Users 2731 not found.
Date Deposited:	19 Oct 2011 10:17
Last Modified:	09 Dec 2024 01:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/35052
DOI:	10.1371/journal.pone.0023713

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