A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

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Friščić, T, Halasz, I, Strobridge, FC, Dinnebier, RE, Stein, RS, Fabian, L and Curfs, C (2011) A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding. CrystEngComm, 13 (9). pp. 3125-3129. ISSN 1466-8033

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Official URL: http://dx.doi.org/10.1039/c0ce00894j

Abstract

Variation of water content in liquid-assisted grinding was utilised to mechanochemically screen for different hydrated forms of magnesium naproxen directly from a mixture of magnesium oxide and naproxen. Structure determination from powder and single crystal X-ray diffraction data, supported by solid-state NMR and synchrotron radiation diffraction experiments, revealed a monohydrate coordination polymer, a discrete tetrahydrate complex, and provided a preliminary structural model for a highly hydrated salt.

Item Type:	Article
Depositing User:	Users 2731 not found.
Date Deposited:	18 Oct 2011 13:09
Last Modified:	18 Oct 2011 13:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/35044
DOI:	10.1039/c0ce00894j

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