Synthesis and antimicrobial activity of brominated resorcinol dimers

Bouthenet, Elise, Oh, Ki-Bong, Park, Seungil, Nagi, Navjeet K., Lee, Hyi-Seung and Matthews, Susan E. ORCID: https://orcid.org/0000-0001-8821-0851 (2011) Synthesis and antimicrobial activity of brominated resorcinol dimers. Bioorganic & Medicinal Chemistry Letters, 23 (23). pp. 7142-7145. ISSN 1464-3405

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Abstract

Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6’-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase C. albicans.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Users 2731 not found.
Date Deposited:	12 Oct 2011 10:09
Last Modified:	08 May 2024 00:45
URI:	https://ueaeprints.uea.ac.uk/id/eprint/34989
DOI:	10.1016/j.bmcl.2011.09.072

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