Shiga toxin interaction with human intestinal epithelium

Schuller, Stephanie ORCID: https://orcid.org/0000-0003-3260-9112 (2011) Shiga toxin interaction with human intestinal epithelium. Toxins, 3 (6). pp. 626-639. ISSN 2072-6651

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Abstract

After ingestion via contaminated food or water, enterohaemorrhagic E. coli colonises the intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has been described so far, and it is assumed that Stx are released into the gut lumen after bacterial lysis. Human intestinal epithelium does not express the Stx receptor Gb3 or other Stx binding sites, and it remains unknown how Stx cross the intestinal epithelial barrier and gain access to the systemic circulation. This review summarises current knowledge about the influence of the intestinal environment on Stx production and release, Stx interaction with intestinal epithelial cells and intracellular uptake, and toxin translocation into underlying tissues. Furthermore, it highlights gaps in understanding that need to be addressed by future research.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	Rhiannon Harvey
Date Deposited:	20 Jul 2011 10:18
Last Modified:	24 Sep 2024 08:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33976
DOI:	10.3390/toxins3060626

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