A new facile method for spin-labeling of oligonucleotides

Strube, Thorsten, Schiemann, Olav, Macmillan, Fraser ORCID: https://orcid.org/0000-0002-2410-4790, Prisner, Thomas and Engels, Joachim W. (2001) A new facile method for spin-labeling of oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids, 20 (4-7). pp. 1271-1274. ISSN 1525-7770

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A new facile method for spin-labeling suitable for DNA and RNA oligonucleotides is presented. The nitroxide 3-ethenyl-2,2,5,5-tetramethyl-pyrrolin-1-yloxy was directly introduced during automated solid-phase synthesis by a Pd(0) cross coupling reaction. The main advantages of this procedure are the small amount of spin-label needed for the derivatisation of the oligonucleotide and the high coupling efficiency on the solid phase.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 18 Jul 2011 15:55
Last Modified: 24 Oct 2022 03:46
URI: https://ueaeprints.uea.ac.uk/id/eprint/33888
DOI: 10.1081/NCN-100002534

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