Intraepithelial γδ+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection

Dalton, Jane E, Cruickshank, Sheena M, Egan, Charlotte E, Mears, Rainy, Newton, Darren J, Andrew, Elizabeth M, Lawrence, Beth, Howell, Gareth, Else, Kathryn J, Gubbels, Marc-Jan, Striepen, Boris, Smith, Judith E, White, Stanley J and Carding, Simon R (2006) Intraepithelial γδ+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection. Gastroenterology, 131 (3). pp. 818-829. ISSN 1528-0012

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Abstract

Intestinal epithelial integrity and permeability is dependent on intercellular tight junction (TJ) complexes. How TJ integrity is regulated remains unclear, although phosphorylation and dephosphorylation of the integral membrane protein occludin is an important determinant of TJ formation and epithelial permeability. We have investigated the role intestinal intraepithelial lymphocytes (iIELs) play in regulating epithelial permeability in response to infection.

Item Type:	Article
Uncontrolled Keywords:	animals,blotting, western,cell membrane permeability,disease models, animal,immunohistochemistry,immunoprecipitation,intercellular junctions,intestinal mucosa,male,membrane proteins,mice,mice, inbred c57bl,occludin,phosphorylation,rna,receptors, antigen, t-cell, gamma-delta,reverse transcriptase polymerase chain reaction,t-lymphocytes,toxoplasma,toxoplasmosis, animal
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	14 Jul 2011 11:07
Last Modified:	10 Feb 2023 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33717
DOI:	10.1053/j.gastro.2006.06.003

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