Gammadelta T cells: Functional plasticity and heterogeneity

Carding, Simon R and Egan, Paul J (2002) Gammadelta T cells: Functional plasticity and heterogeneity. Nature Reviews Immunology, 2 (5). pp. 336-345. ISSN 1474-1733

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Abstract

Gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their biological function(s) remains unclear. On the basis of studies of gammadelta T cells in infectious and autoimmune diseases, we argue that gammadelta T cells perform different functions according to their tissue distribution, antigen-receptor structure and local microenvironment; we also discuss how and at what stage of the immune response they become activated.

Item Type:	Article
Uncontrolled Keywords:	animals,autoantigens,autoimmune diseases,cell lineage,disease models, animal,genes, t-cell receptor,humans,immunologic surveillance,infection,mice,receptors, antigen, t-cell, gamma-delta,t-lymphocytes
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	14 Jul 2011 11:01
Last Modified:	21 Oct 2025 07:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33714
DOI:	10.1038/nri797

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