An H-NS-like Stealth Protein Aids Horizontal DNA Transmission in Bacteria

Doyle, Marie, Fookes, Maria, Ivens, Al, Mangan, Michael W., Wain, John and Dorman, Charles J. (2007) An H-NS-like Stealth Protein Aids Horizontal DNA Transmission in Bacteria. Science, 315 (5809). pp. 251-252. ISSN 0036-8075

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The Sfh protein is encoded by self-transmissible plasmids involved in human typhoid and is closely related to the global regulator H-NS. We have found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness. Introducing the plasmid without the sfh gene imposes a mild H-NS– phenotype and a severe loss of fitness due to titration of the cellular pool of H-NS by the A+T-rich plasmid. This stealth strategy seems to be used widely to aid horizontal DNA transmission and has important implications for bacterial evolution.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 12 Jul 2011 11:03
Last Modified: 21 Apr 2020 19:16
DOI: 10.1126/science.1137550

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