An H-NS-like stealth protein aids horizontal DNA transmission in bacteria

Doyle, Marie, Fookes, Maria, Ivens, Al, Mangan, Michael W., Wain, John and Dorman, Charles J. (2007) An H-NS-like stealth protein aids horizontal DNA transmission in bacteria. Science, 315 (5809). pp. 251-252. ISSN 0036-8075

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Abstract

The Sfh protein is encoded by self-transmissible plasmids involved in human typhoid and is closely related to the global regulator H-NS. We have found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness. Introducing the plasmid without the sfh gene imposes a mild H-NS– phenotype and a severe loss of fitness due to titration of the cellular pool of H-NS by the A+T-rich plasmid. This stealth strategy seems to be used widely to aid horizontal DNA transmission and has important implications for bacterial evolution.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Medical Microbiology (former - to 2018)
Depositing User:	Rhiannon Harvey
Date Deposited:	12 Jul 2011 11:03
Last Modified:	16 Jan 2024 01:21
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33539
DOI:	10.1126/science.1137550

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